Willingness to participate in entheogen use research in naturalistic settings

Abstract Background Entheogen use is becoming increasingly popular and a potential option for treatment or adjuvant various medical conditions. Clinical studies are needed to determine the efficacy, safety, possible role of these traditional medicines in context modern society Western medicine paradigm. The willingness patients participate such currently unknown. Materials Methods In September 2021 we implemented an anonymous, observational pilot survey general public's future entheogen research. All participants were English-speaking adults had participated therapy retreat utilizing entheogens naturalistic setting last five (5) years. Participants recruited through community outreach via email. Results response rate this data set was estimated be 48.3% ( n = 84/174). Nearly all (95.5%) believed research should done 86.9% said they would that lasted longer than one year. A greater proportion willing remote interviews (73.5%) rather in-person surveys (64.7%). majority (78%) also noted importance financial compensation their time influencing studies. Conclusions involving not limiting factor facilitating further held overwhelmingly positive perceptions indicating done. Future longitudinal clinical with controlled settings will necessary expand evidence base use.